Talk:Ketamine

This is the talk page for discussing improvements to the Ketamine article.
This is not a forum for general discussion of the article's subject.

Put new text under old text. Click here to start a new topic.
New to Wikipedia? Welcome! Learn to edit; get help.

Article policies

Find medical sources: Source guidelines · PubMed · Cochrane · DOAJ · Gale · OpenMD · ScienceDirect · Springer · Trip · Wiley · TWL

Archives: Index, 1, 2, 3: 12 months

Article milestones
Date	Process	Result
September 1, 2009	Peer review	Reviewed

Pharmacology High‑importance

	This article is within the scope of WikiProject Pharmacology, a collaborative effort to improve the coverage of Pharmacology on Wikipedia. If you would like to participate, please visit the project page, where you can join the discussion and see a list of open tasks.PharmacologyWikipedia:WikiProject PharmacologyTemplate:WikiProject Pharmacologypharmacology
High	This article has been rated as High-importance on the project's importance scale.

Medicine High‑importance

	Medicine portal This article is within the scope of WikiProject Medicine, which recommends that medicine-related articles follow the Manual of Style for medicine-related articles and that biomedical information in any article use high-quality medical sources. Please visit the project page for details or ask questions at Wikipedia talk:WikiProject Medicine.MedicineWikipedia:WikiProject MedicineTemplate:WikiProject Medicinemedicine
High	This article has been rated as High-importance on the project's importance scale.

Altered States of Consciousness High‑importance

	This article is within the scope of WikiProject Altered States of Consciousness, a collaborative effort to improve the coverage of altered states of consciousness on Wikipedia. If you would like to participate, please visit the project page, where you can join the discussion and see a list of open tasks.Altered States of ConsciousnessWikipedia:WikiProject Altered States of ConsciousnessTemplate:WikiProject Altered States of ConsciousnessAltered States of Consciousness
High	This article has been rated as High-importance on the project's importance scale.

Chemicals Mid‑importance

	This article is within the scope of WikiProject Chemicals, a daughter project of WikiProject Chemistry, which aims to improve Wikipedia's coverage of chemicals. To participate, help improve this article or visit the project page for details on the project.ChemicalsWikipedia:WikiProject ChemicalsTemplate:WikiProject Chemicalschemicals
Mid	This article has been rated as Mid-importance on the project's importance scale.

Psychoactive and Recreational Drugs (defunct)

This article is within the scope of WikiProject Psychoactive and Recreational Drugs, a project which is currently considered to be defunct.Psychoactive and Recreational DrugsWikipedia:WikiProject Psychoactive and Recreational DrugsTemplate:WikiProject Psychoactive and Recreational DrugsPsychoactive and Recreational Drugs

Rave (inactive)

This article is within the scope of WikiProject Rave, a project which is currently considered to be inactive.RaveWikipedia:WikiProject RaveTemplate:WikiProject RaveRave

This article has been viewed enough times in a single week to appear in the Top 25 Report. The week in which this happened:

August 11 to 17, 2024

The following Wikipedia contributor has declared a personal or professional connection to the subject of this article. Relevant policies and guidelines may include conflict of interest, autobiography, and neutral point of view.

Geraldwgaines (talk · contribs) This user has contributed to the article. This user has declared a connection. (COI declared at User talk:Geraldwgaines here.)

2-Cl-2’-oxo-PCM

Ideal sources for Wikipedia's health content are defined in the guideline Wikipedia:Identifying reliable sources (medicine) and are typically review articles. Here are links to possibly useful sources of information about Ketamine.

PubMed provides review articles from the past five years (limit to free review articles)
The TRIP database provides clinical publications about evidence-based medicine.
Other potential sources include: Centre for Reviews and Dissemination and CDC

Archives

1, 2, 3

This page has archives. Sections older than 365 days may be automatically archived by when more than 5 sections are present.

Article on the impact and concerns of enabling legal tele-medicine ketamine prescriptions

There's evidence of addiction and toxic effects from telemedicine prescriptions of ketamine in the US. [1]https://www.nytimes.com/2023/02/20/us/ketamine-telemedicine.html?smid=url-share Neiabr (talk) 18:32, 25 February 2023 (UTC)[reply]

NYT is fully paywalled so it might as well not exist. Even closed-access journals provide abstracts. NYtimes isn't a reliable medical source, anyway. A Shortfall Of Gravitas (talk) 05:39, 26 April 2025 (UTC)[reply]

Including role of glutamate in antidepressant effects

Currently, under the "Mechanism of action," the article states: "In any case, it has been elucidated that acute blockade of NMDA receptors in the brain results in an activation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPA receptors), which in turn modulate a variety of downstream signaling pathways to influence neurotransmission in the limbic system and mediate antidepressant effects of NMDA receptor antagonists like ketamine." The article does not address why the acute blockade of NMDA receptors in the brain results in an activation of AMPA receptors, which is very important to the explanation. The most accepted explanation of this appears to be due to a "glutamate surge".

This except explains it well: "Subanesthetic-dose ketamine administration leads to immediate presynaptic disinhibition of glutamatergic neurons, producing a glutamate surge (Moghaddam et al., 1997). This surge is thought to result from the blockade of NMDA receptors targeting γ-aminobutyric acid-ergic interneurons, leading to local inhibition of interneuron tonic firing and subsequent disinhibition of glutamate transmission (Homayoun and Moghaddam, 2007). Due to a blockade of NMDA receptors on postsynaptic excitatory neurons, excess synaptic glutamate is primarily taken up by AMPA receptors, thereby activating neuroplasticity-related signaling pathways (including mammalian target of rapamycin complex 1 (Li et al., 2010; Li et al., 2011) and brain-derived neurotrophic factor (Liu et al., 2012), both of which result in increased synaptogenesis and synaptic potentiation)." Gilbert JR, Yarrington JS, Wills KE, Nugent AC, Zarate CA (August 2018). "Glutamatergic Signaling Drives Ketamine-Mediated Response in Depression: Evidence from Dynamic Causal Modeling". The International Journal of Neuropsychopharmacology. 21 (8): 740–747. doi:10.1093/ijnp/pyy041. PMC 6070027. PMID 29668918.

I am thinking that the sentence should be changed to something to the effect of: "In any case, it has been elucidated that acute blockade of NMDA receptors in the brain results in an increase in glutamate production, which leads to an activation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPA receptors), which in turn modulate a variety of downstream signaling pathways to influence neurotransmission in the limbic system and mediate antidepressant effects of NMDA receptor antagonists like ketamine." Wikipedialuva (talk) 08:31, 11 October 2023 (UTC)[reply]

Agreed, please change. 2001:9E8:4629:A400:F5BF:1E33:500D:E6E2 (talk) 21:02, 17 December 2023 (UTC)[reply]

Long form chemical name of Ketamine (2-Cl-2’-oxo-PCM)

I think the long form chemical name of Ketamine (2-Cl-2’-oxo-PCM) should be added to the article. Who else has been looking for this information but can not find it? Daimontoppi (talk) 15:44, 5 November 2024 (UTC)[reply]

Do you have a reliable source the indicates that is another name for ketamine? OhNoitsJamie ^Talk 15:58, 5 November 2024 (UTC)[reply]